Magnetic microparticle size optimization for susceptibility contrast imaging
نویسندگان
چکیده
Superparamagnetic nanoparticles (SPIOs) and magnetic microparticles (MPIOs) are used as contrast enhancers in magnetic resonance imaging (MRI) [1, 2]. Compared to nanofabricated contrast agents, micrometer-sized agents can benefit from higher magnetic moments. As a result, susceptibility artifact (hypointense signal) is increased and visibility improves in MR images [3]. Magnetic moment of a micrometer-sized particle is a function of saturation magnetization and volume of the particle. Since MRI’s external magnetic field (B0) magnetizes ferromagnetic and superparamagnetic particles to saturation, the total magnetic moment and so the amount of the susceptibility artifact is determined by the volume of the particle. In the present work, a numerical simulation is used to investigate the behavior of the susceptibility artifact as magnetic microparticles are broken to smaller microparticles. Depending on the size of the constituent microparticles, different ensembles with identical total magnetic volume are considered. Introduction
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